Erythrokinetics in the megaloblastic anemia of tropical sprue.

The effect of "minute" and "titrated" amounts of folic acid on the megaloblastic anemia of tropical sprue.

Tropical sprue: revisited.

OBJECTIVE To review the experience of patients presenting with clinical manifestations of tropical sprue and assess their diagnosis and management, response to treatment and follow up. METHODS This single center retrospective descriptive study was done at Shifa International Hospital, Islamabad from January 1994 to January 2003. All patients who presented with diarrhea, anorexia, weight loss ...

Absorption of Physiologic Doses of Folic Acid in Subjects with Tropical Sprue Responding to Tetracycline Therapy

T HE MEGALOBLASTIC ANEMIA which is characteristically present in persons with advanced tropical sprue is usually due to a combined deficiency of folate and vitamin B12.1 Deficiency of vitamin B12 in this condition has been clearly demonstrated to be secondary to malabsorption of this vitamin.’ The factors responsible for folate deficiency are less well-defined. Impaired absorption of pharmacolo...

Vitamin B 12 and tropical sprue.

Manson in 1883 advocated the use of a folk remedy, liver soup, for the treatment of tropical sprue. Subsequently, with the development of morphological haematology, it was recognized that there were some similarities between tropical sprue and pernicious anaemia (Reed & Wyckoff, 1926). After Minot & Murphy (1926) demonstrated the effectiveness of liver therapy in pernicious anaemia, detailed st...

Absorption of physiologic doses of folic acid in subjects with topical sprue responding to tetracycline therapy.

T HE MEGALOBLASTIC ANEMIA which is characteristically present in persons with advanced tropical sprue is usually due to a combined deficiency of folate and vitamin B12.1 Deficiency of vitamin B12 in this condition has been clearly demonstrated to be secondary to malabsorption of this vitamin.’ The factors responsible for folate deficiency are less well-defined. Impaired absorption of pharmacolo...